WebControlling the nucleation step of a self-assembly system is essential for engineering structural complexity and dynamic behaviors. Here, we design a "frame-filling" model … To minimise the impact of freezing variability during the freezing step in a lyophilisation cycle, various concepts have been presented to manipulate or even control nucleation. In general, uncontrolled nucleation occurs over a wide range of product temperatures (typically between -5°C and -15°C in the … See more The nature of ice nucleation is spontaneous and random, and the effective nucleation temperature depends on several aspects. These factors include solution properties, process conditions, environmental … See more A set of laboratory experiments were conducted to evaluate the influence of different freezing regimes (including random shelf freezing, annealing and controlled nucleation) on drying performance. A 75 … See more Since identical secondary drying conditions were used in all experiments (heating rate: 0.1°C/minute to +40°C, six hours secondary … See more Product microstructure analysed by SEM (scanning electron microscopy) confirmed the increase in ice crystal size and corresponding pore size (Figure 5, page 66). The macroscopic cake elegancy was overall acceptable … See more
Controlled Ice Nucleation Using ControLyo - Springer
WebIn such applications, controlled nucleation and stabilization of domain walls are critical. Here, using in situ transmission electron microscopy and phase-field simulations, a controlled nucleation of vertically oriented 109° domain walls in (110)-oriented BiFeO3(BFO) thin films is reported. WebNov 4, 2024 · To overcome limitations, various methods and technologies have been investigated to initiate nucleation and optimize the drying process. The most common of these include the addition of an annealing cycle or the use of a controlled nucleation technique, such as pressurization and depressurization technique. budweiser select mini fridge
Unexplored benefits of controlled ice nucleation: Lyophilization …
WebDec 19, 2024 · Controlled Ice Nucleation (CIN) presents such an opportunity for users, by allowing for reduced variability in drug product resistance as well as reduced intra and inter- batch variability of product quality attributes. Further, with CIN, a more aggressive cycle can be achieved, without collapse. WebDec 18, 2013 · The controlled nucleation cycle was more than 40% shorter than the cycle run without controlling nucleation. In the controlled nucleation run, larger ice crystals were formed that resulted in larger pores, less resistance to mass flow, and higher sublimation rates during the freeze-drying process, resulting in reduced cycle time. ... WebNov 4, 2024 · To overcome limitations, various methods and technologies have been investigated to initiate nucleation and optimize the drying process. The most common of … crislu wholesale