Heteroarylalkyl
WebJan 27, 2024 · A new and efficient method for the hydroxylation of heteroarylalkyl, arylalkyl and alkyl halides has been developed by exploiting the nucleophilicity of water. The method being operated under neutral conditions, avoids acid/base or metal assisted catalysis. The protocol has been optimized for a range of aqueous aprotic/protic solvents. WebContextual translation of "hétéroarylalkyle" into English. Human translations with examples: heteroarylalkyl, alkyl, heteroaryl.
Heteroarylalkyl
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WebJul 15, 2024 · These results encouraged us to further investigate the structure-activity relationships within this series. Hence, we herein report the design and pharmacological … Web2α-Heteroarylethyl-1α,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a nitrogen …
Vdr(R270L) rats at 6 weeks of age were orally administered with AH-1 five times a week for 8 weeks (Fig. 3). As previously reported11, Vdr(R270L) rats without AH-1 treatment showed bone disorders, including decreased bone mineral density (BMD) of cortical bones and hyperplasia of trabecular bones in the … See more In our previous study, we developed a bioluminescent sensor of VDR ligands consisting of split-luciferase and LBD of the human VDR20,21,22. Furthermore, we … See more Computational docking was performed to construct a model of Vdr(R270L) complex with 1,25(OH)2D3 or AH-1, The complex structures demonstrated that … See more The calcemic actions of 1,25(OH)2D3 via VDR are the most important molecular mechanisms underlying the osteogenic effect of vitamin D. We … See more The duodenum and kidneys are important target organs of vitamin D, and are involved in vitamin D-dependent calcium absorption and reabsorption, … See more WebProvided herein (alpha] substituted aralkyl or heteroarylalkyl amino) pyrimidin-yl and 1,3,5-triazin-benzimidazole, for example, a compound of Formula I, and pharmaceutical compositions thereof , preparation and use as pharmaceutical agents or for the treatment of a proliferative disease uses.
WebDisclosed herein are small molecule GIP/GLP-1 dual receptor agonist compositions, pharmaceutical compositions, the use and preparation thereof. WebThe present disclosure relates to compositions and methods useful for the functionalization of surfaces in the absence of a metal catalyst. The compositions include compounds of f
Webheterocyclylalkyl, heteroaryl, heteroarylalkyl, heteroaryloxy, heteroaryloxyalkyl or C(R8)(R9)(R10), N(R4)(R5) or OR6, wherein any free hydroxyl group may be 25 acylated to form C(O)R7; R4 and R5 each independently represent H or substituted or unsubstituted alkyl, hydroxyalkyl, acyl, aminoalkyl, acylaminoalkyl, alkenyl, alkoxyalkyl, aryl,
the pingu show 2006Webeach comonomer comprises a hydrocarbylene group wherein one or more methylene groups of the hydrocarbylene group is optionally replaced by a group Y (provided that none of the Y g the ping storeWebFeb 15, 2016 · Primary alkyl bis-catecholato silicates have been successfully engaged with aryl and heteroaryl bromide substrates in photoredox/nickel dual catalysis to provide aryl- … the pingu show iviWebJul 15, 2024 · These results encouraged us to further investigate the structure-activity relationships within this series. Hence, we herein report the design and pharmacological characterization of novel 2-(2-furanyl)-thiazolo [5,4-d]pyrimidine-5,7-diamine derivatives (4–13) substituted at the N 5 nitrogen atom with a heteroarylalkyl chain . the pingu danceWebA B-N-containing organic electroluminescent material and the use thereof in an electroluminescent device, wherein the material has structures as shown in general formulae (I), (II), and (III). The material on the basis of a B-N structure has an electron-withdrawing-N structural unit introduced thereto, such that the multiple resonance effect of the B-N … the pingu show on cbeebiesWebOct 27, 2006 · The versatility of the method is explored with 23 examples representing a wide range of alkyne variations (arylalkyl-, dialkyl-, heteroarylalkyl-) and diaryl- as well as arylalkylcyclopropenones. The reactions often proceed in high yield using minimal catalyst loadings and in all cases examined proceed with high or complete regioselectivity. the pingu movieWebMonochlorination of Electron-Rich Arylalkyl- and Heteroarylalkyl-Amines and Amino Acids Using Sulfuryl Chloride. Guixue Yu, Guixue Yu. Discovery Chem., Bristol-Myers Squibb, … the pingu show vimeo