Triethylenephosphoramide
WebJun 3, 2024 · 1. Introduction. N, N’ N”-triethylenethiophosphoramide (thiotepa) and cyclophosphamide (CP) are alkylating agents with many clinical indications that include … WebJun 30, 2024 · Thiotepa undergoes oxidative desulphuration via the cytochrome P450 CYP2B and CYP3A isoenzyme families to the major and active metabolite TEPA (triethylenephosphoramide). The total excreted amount of thiotepa and its identified metabolites accounts for 54-100% of the total alkylating activity, indicating the presence …
Triethylenephosphoramide
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WebBuy Triethylenephosphoramide online from Pharmaceutical toxicology. Certified reference materials for highly accurate and reliable data analysis. WebRequest PDF Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N′,N″-triethylenethiophosphoramide (thiotepa) and N,N′,N″-triethylenephosphoramide (tepa) in ...
WebFeb 1, 2000 · The degradation of N,N',N"-triethylenephosphoramide (TEPA) in aqueous solutions has been investigated over a pH range of 3-14. Samples were analyzed using a gas chromatographic system with nitrogen/phosphorus selective detection. The degradation kinetics were studied as function of pH, sodium chloride concentration and temperature. WebFeb 6, 2024 · Prior to intravesical administration, patients should be dehydrated for 8–12 hours. Instill 60 mL of diluted thiotepa solution by catheter into the bladder; retain solution in the bladder for 2 hours for maximum effect. Reposition patient every 15 minutes for maximum area contact. If patient is unable to retain 60 mL for 2 hours, instill 30 mL.
WebClinical studies on triethylenephosphoramide and diethylenephosphoramide, compounds with nitrogen-mustard-like activity Weblife of 1–3 hours. Triethylenephosphoramide (TEPA), a metabolite of thiotepa, is detected in plasma 5–10 minutes after intravenous injection, and persists longer in plasma with a half-life of 3–21 hours. Both thiotepa and TEPA penetrate the cerebrospinal fluid (IARC, 1990; Maanen et al., 2000). The urinary excretion of unchanged thiotepa
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WebBuy high quality Triethylenephosphoramide-d12 1246816-29-4 from toronto research chemicals Inc. natural glasses cleaner recipeWebTRIETHYLENEPHOSPHORAMIDE (TEPA) TEPA is a hygroscopic solid that is soluble but relatively unstable in water. At the suggestion of one of us (F. P.) a stable solution was pre- pared in peanut oil for intramuscular injection. The preparation was first made available by the Lederle Laboratories as 1 and 2 per cent maria pappas cook county treasurer\\u0027s officeWebSimultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in … maria pappas twitterWebTRIETHYLENEPHOSPHORAMIDE (TEPA) TEPA is a hygroscopic solid that is soluble but relatively unstable in water. At the suggestion of one of us (F. P.) a stable solution was pre … maria pappas property tax searchWebOct 20, 2024 · Thiotepa is rapidly metabolized to triethylenephosphoramide (TEPA). Thiotepa and TEPA are alkylating agents that both appear to contribute to the carcinogenic effects. There is strong evidence that both thiotepa and TEPA form DNA adducts and DNA cross-links. Thiotepa is cytotoxic and produces mutations. natural glass rocksWebTriethylenephosphoramide Accession Number DBCAT001594 Description. An insect chemosterilant and an antineoplastic agent. Drugs. Drug Drug Description; Thiotepa: An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder … natural glam wedding makeup african americanWebTriethylenephosphoramide Add to My Records Monograph ID: M11107. Title: Triethylenephosphoramide Molecular Formula: C 6 H 12 N 3 OP Molecular Weight: 173.16 … maria papas cook treasurer.com